In the Netherlands, PhenocaneTM is manufactured as a food supplement according to the international regulations for the production of pharmaceuticals. Phenocane is often used for patients with chronic degenerative and inflammatory diseases associated with pain. Millions of people deal with chronic pain caused by inflammation on a daily basis unable to enjoy regular life activities without being slowed down by pain. PhenocaneTM is particularly effective for those suffering from arthritis, sciatica, back pain, or injuries that continue to cause inflammation, the root cause of most chronic pain conditions. If inflammation can effectively be reduced, then pain can also be managed. A special prostaglandin, called PGE1, is one of the primary compounds involved in the inflammation process. Prostaglandins are found in most tissues and organs; they can be produced by almost all nucleated cells in our body. They are synthesized in the cell from essential fatty acids and function as autocrine and paracrine lipid mediators acting upon platelets, endothelium, uterine- and mast cells. When an inflamed or injured tissue (for example muscle, bone, cartilage) generates PGE1, pain perception from this body area will be enhanced and magnified, signaling that something is wrong. Then our body usually initiates repair of the injured or inflamed tissue. During this repair process, however, inflammation is often sustained for a while by an enzyme called Cyclooxygenase 2 (COX2). Inhibition of this enzyme has become an important treatment approach in controlling inflammation and hence pain.
Phenocane provides effective pain relief and decreases inflammation by inhibiting exactly this COX2 enzyme. Recently, other COX2 inhibitors such as Celebrex and Vioxx had become rather popular for reducing inflammation and pain. Unfortunately, studies showed that these COX2 inhibitors had some damaging side effects: they caused strokes and heart attacks by inducing blood clots. Consequently, they were taken from the market. PhenocaneTM has not been found to promote any negative or dangerous side effects, thus making it safe for long-term and continual use.
There three natural ingredients in Phenocane are working perfectly together, creating a powerful anti-inflammatory compound and pain reliever which offers maximum health benefits in a safe and gentle way.
Effects of the individual ingredients of PhenocaneTM: Biocurcumin BCM95®
Biocurcumin BCM95 is a patented extract made from turmeric, which possesses a number of biological attributes, such as antioxidant, anti-inflammatory, antibacterial, and anti- rheumatic effects, as well as a significant effect. In contrast to normal turmeric extract, Biocurcumin BCM95 possesses an extremely high bioavailability (about seven times as great). That means that an oral dosage of only 250 mg of Biocurcumin BCM95 achieve approximately the same blood- drug level as a dosage of 1,500 mg of normal turmeric extract, or about 37,500 mg of simple Curcumin Powder. Therefore, taking Biocurcumin BCM95 quickly delivers a therapeutic concentration of curcuminoids into the blood stream.
The BCM95 Complex distinguishes itself with the following positive properties:
- 100% natural turmeric extract (Curcuma longa) without added artificial ingredients
- clinical studies show that BCM95 Extract has its is bioavailability 7-8 times that of othercurcumin extracts
- much smaller dosages than conventional curcumin extracts achieve the same effect
- has a powerful antioxidant effect
- has extremely good anti-inflammatory propertiesCurcuminoids extracted from curcumin (turmeric root powder) are very powerful COX2 inhibitors, and they are the key ingredient of PhenocaneTM. Curcumin is widely recognized as having powerful anti-inflammatory properties. It has been shown to be as effective in reducing inflammation as the pharmaceutical drug, cortisone; however, it does not have the side effects known from long-term use of corticosteroids.
From a pain-treatment standpoint, the anti- inflammatory and antioxidant properties of the curcuminoids are very important, since these contribute to its pain-relieving efficacy. However, curcumin and its various biologically active molecules also have anti- carcinogenic and anti-metastatic effects, which are used in complementary treatments. Clinical tests and studies conducted on animals confirm in particular the anti-inflammatory efficacy of this curcumin complex.
DL Phenylalanine (DLPA)
DLPA contains two forms of the amino acid, phenylalanine. The “L” form is a natural substance found in many protein-rich foods. It increases mood-elevating chemicals in the brain, such as dopamine and norepinephrine. The “D” form of phenylalanine is made synthetically and it blocks a nervous system enzyme that amplifies pain signals. In addition, DLPA inhibits the breakdown of the brain’s natural narcotics, such as endorphin, and increases the levels of serotonin, a hormone produced in the brain that promotes mood elevation and reduces pain perception.
DLPA has been shown to help relieve certain types of chronic pain, including muscle aches and persistent arthritis-related pain by inhibiting the actions of a pain-inducing protein, called enkephalinase. Some scientists speculate that DLPA also helps by boosting the effectiveness of narcotics and other pain medications. Preliminary evidence also indicates that DLPA, when taken in conjunction with opiates for pain, may increase efficacy of the conventional medications and reduce the dosage of opiates required to treat pain.
Boswellia serrata extract
Extracts of Boswellia serrata have been clinically confirmed to have beneficial effects for patients with osteoarthritis and painful joints, particularly osteoarthritis of the knee. Positive effects of Boswellia were also described in other chronic inflammatory diseases, including rheumatoid arthritis, bronchial asthma, ulcerative colitis and Crohn’s disease. Boswellia serrata extracts are inhibiting COX2 in the body, enhancing the pain relieving activity of Phenocane.
Benefits of Phenocane:
• Reduces inflammation
• Relieves from chronic pain
• Decreases recurrent pain associated with arthritis, back pain, sciatica, etc.
• Diminishes swelling and stiffness